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MYP_053652
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Basic Information
Cycloviolacin Y4
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
30 amino acids
C127H202N32O41S6
Standard
Sequence
GVPCGESCVFIPCITGVIGCSCSSNVCYLN
Physicochemical Analysis
3025.54 Da
4.05
-1.30
-1.59
-0.0432
1.05
0.31
0.39
36.82
90.67
0.0667
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1134.50
-14.46
44.0
46.0
91.0
206.0
4.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0253296 VERIFIED: YES
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-20; 8-22; 13-27
Bio-Activity Profile
Antimicrobial Antiviral
HIV inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells
0.12 μM
EC50
PaperPubMed PMID: 18081258 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. | PubMed PMID: 18618891 PMID18081258;18008336;18618891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18081258/
RECORD: Rec_0261917 VERIFIED: YES
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antiviral Anti-HIV Nematocidal Anthelmintic Hemolytic
Haemonchus contortus
PaperThe anthelmintic activity of the cyclotides: natural variants with enhanced activity | PubMed PMID 18081250 PMID18081250 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18081250/
RECORD: Rec_0268717 VERIFIED: NO
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
backbone-cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral Hemolytic
RECORD: Rec_0276140 VERIFIED: YES
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-20; 8-22; 13-27
Bio-Activity Profile
Antimicrobial Antiviral Hemolytic
human type A red blood cells
PaperPubMed PMID: 18081258 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. | PubMed PMID: 18618891 PMID18081258;18008336;18618891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18081258/
RECORD: Rec_0278583 VERIFIED: YES
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization (N termini to C termini)
Cyclization (N termini to C termini)
4-20, 8-22, 13-27
Disulfide bonds between Cys4 and Cys20; Cys8 and Cys22; Cys13 and Cys27.
Bio-Activity Profile
Antiviral Entry inhibition
Effects
2.27 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperPMID:18618891 PMID18618891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18618891/
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