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MYP_053652
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Basic Information
Cycloviolacin Y4
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
30 amino acids
C127H202N32O41S6
Standard
Sequence
GVPCGESCVFIPCITGVIGCSCSSNVCYLN
Physicochemical Analysis
3025.54 Da
4.05
-1.30
-1.59
-0.0432
1.05
0.31
0.39
36.82
90.67
0.0667
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1134.50
-14.46
44.0
46.0
91.0
206.0
4.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0182357 VERIFIED: YES
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-20; 8-22; 13-27
Bio-Activity Profile
Antimicrobial Antiviral
contortus( IC50=2.01μM, IC99=6.73μM) and T
PaperPubMed PMID: 18081258 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. | PubMed PMID: 18618891 PMID18081258;18008336;18618891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18081258/
RECORD: Rec_0220558 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Cyclotide
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV
Human erythrocytes
9.3 μM
Paperhttps://pubmed.ncbi.nlm.nih.gov/18081258/ PMID18081258 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18081258/
RECORD: Rec_0222112 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide; DSSP H 20.0%, E 6.7%, T 40.0%, C 33.3% [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Toxic Antimicrobial Hemolytic Cytotoxic
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0223828 VERIFIED: YES
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antiviral Anti-HIV Nematocidal Anthelmintic Hemolytic
Trichostrongylus colubriformis
PaperThe anthelmintic activity of the cyclotides: natural variants with enhanced activity | PubMed PMID 18081250 PMID18081250 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18081250/
RECORD: Rec_0239924 VERIFIED: YES
Provenance & Taxonomy
Viola yedoensis [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-20; 8-22; 13-27
Bio-Activity Profile
Antimicrobial Antiviral
colubriformis
2.27 μM
IC50
PaperPubMed PMID: 18081258 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. | PubMed PMID: 18618891 PMID18081258;18008336;18618891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18081258/
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