Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length487 amino acids

Chemical FormulaC2404H3811N635O685S20

DescriptionStandard

        MREDMARGPDNSPRRALLAVLAAVGTAMTAAISPGAVARISQKGLDYACQEGTAVLRKELEKIEIPDYSRKFKIKPLGKGNYSFYSMNVRGFQLPSPQIPLVPNVGLKLFIGNASVKISGKWKAQKSFIKTSGNFDLTVEGISIVADLKMGSDPTSGKPTFACSSCRSHVSSVGVHISGSKLGWLIRLFRENIESSIRNTIQDEICKVVTNSVSSELQPYFQNLPVMTKIDAVAGIDYRLVASPAATSEYLDGHLKGEFFSLAHRIPPPFAPSALELPADHDRMVYLGLSEYFFNTAGLVYYEAGVLKLTLTDEMIPKTSTFRLTTRFFGTFLPEVAKMFPNMNMQLAISVSTPPHLSMQSSGLALTPYLEAETFAILPNSSLASLFLLGLSTNASVEVGATSSRLVGELKLDRLLLELKHSNIGPFPVAPLQAMMDYVVPTLVLPRVNQRLQKGFPLPMPSHVQLYNPMLRSHQGFLLFGADVHHG
    

Molecular Weight53210.12 Da

Isoelectric Point (pI)9.13

Net Charge (pH 7.0)8.46

Net Charge (pH 7.4) 7.52

Charge Density (pH 7.0) 0.0174

GRAVY Index0.05

Hydrophobic Moment 0.71

Boman Index0.12

Instability Index38.39

Aliphatic Index 94.52

Aromaticity 0.0842

Extinction Coeff. Reduced 31860.00

Extinction Coeff. Oxidized 32110.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0356489 VERIFIED: NO

Provenance & Taxonomy

OrganismPropithecus coquereli [Bacterium]

FamilyBPI

Tax ID379532

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence