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MYP_053599
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Basic Information
Brevinin-1Da
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
17 amino acids
C84H154N20O19S2
Standard
Sequence
ILPLLLGKVVCAITKKC
Physicochemical Analysis
1812.37 Da
9.39
2.74
2.50
0.1610
1.47
0.54
0.38
22.08
177.65
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
618.42
-1.47
23.0
24.0
61.0
125.0
1.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0019678 VERIFIED: YES
Provenance & Taxonomy
Rana dalmatina [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
11-17
Bio-Activity Profile
Antimicrobial
the Gram-positive bacterium Staphylococcus aureus
7 μM
MIC
PaperAn atypical member of the brevinin-1 family of antimicrobial peptides isolated from the skin of the European frog Rana dalmatina
RECORD: Rec_0034785 VERIFIED: YES
Provenance & Taxonomy
Rana dalmatina [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
11-17
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
30.0 μM
MIC
PaperJ.M. Conlon et al. / Comparative Biochemistry and Physiology, Part C 137 (2004) 191-196. An atypical member of the brevinin-1 family of antimicrobial peptides isolated from the skin of the European frog Rana dalmatina
RECORD: Rec_0053914 VERIFIED: NO
Provenance & Taxonomy
European frog [Animal]
Brevinin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
11-17
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0109237 VERIFIED: NO
Provenance & Taxonomy
Rana dalmatina [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
11-17
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli, Staphylococcus aureus
RECORD: Rec_0128415 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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