Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2360H3657N593O671S24

DescriptionStandard

        MLPPVIVVLMLISFTCGENPAVQVILTNKGLQYAKHVGAGWIQERLDRVTLPDISGKILGSIYYTFSGVTITRCDFPEPSVEFYQNVTGFKSSISGLSVAVSGRWMTHFGLIHDGGSFDMAIFNMDVSSVVELGKDADGHLSVASVHCEAQVGNVDMQFRGGASWIFQPFVEHFKGRIKGEIEARVCPYVEESIVNLEYHLQAMKVSLNVDENFTFDLPLTGIPLINASSMNLGLKGEFYDIQTHTEPPFEAQPFSVPEQPGYMLSVGLSEFTLNSASYVFYSAGLLQVLITDSMIPPYFHVHLNTSWMGPYIPQLPKMFPGLLMTLQIYAREVPMFSFQPGVVQMGFQGAVKAFAIQPNGTQTPLFKLNVDSKLSGKVWLAGGRLKGSVTLENFTVTLAASEVGTFETDVLEHLMKAGMMLAVGKLNVELGKGVVLPRMMHAQLINTVLGIEKGFITISSDAQVVLTDRGFN
    

Molecular Weight51842.41 Da

Isoelectric Point (pI)5.47

Net Charge (pH 7.0)-11.44

Net Charge (pH 7.4) -12.42

Charge Density (pH 7.0) -0.0242

GRAVY Index0.22

Hydrophobic Moment 0.56

Boman Index0.21

Instability Index29.96

Aliphatic Index 95.33

Aromaticity 0.1015

Extinction Coeff. Reduced 46870.00

Extinction Coeff. Oxidized 47120.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0177071 VERIFIED: NO

Provenance & Taxonomy

OrganismCyclopterus lumpus [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria