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MYP_053540
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Basic Information
Ranatuerin-2ARa (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
28 amino acids
C123H217N35O39S4
Standard
Sequence
GLMDTVKNAAKNLAGQLLDTIKCKMTGC
Physicochemical Analysis
2938.51 Da
8.82
1.74
1.50
0.0621
0.06
0.62
0.05
2.43
90.71
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1217.66
-13.68
43.0
45.0
104.0
201.0
0.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0113745 VERIFIED: YES
Provenance & Taxonomy
Crawfish frog [Animal]
Ranatuerin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
23-28
Bio-Activity Profile
Antimicrobial
PMID12429503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12429503/
RECORD: Rec_0149047 VERIFIED: YES
Provenance & Taxonomy
Rana areolata [Animal]
Ranatuerin
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
23-28
Bio-Activity Profile
Antimicrobial Antibacterial
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP02226
RECORD: Rec_0156722 VERIFIED: YES
Provenance & Taxonomy
Lithobates areolatus [Animal]
Ranatuerin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
23-28
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
100.0 μM
HC50
PaperM.F. Ali et al. / Biochimica et Biophysica Acta 1601 (2002) 55-63. Antimicrobial peptides and protease inhibitors in the skin secretions of the crawfish frog, Rana areolata
RECORD: Rec_0169854 VERIFIED: YES
Provenance & Taxonomy
Lithobates chiricahuensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0207017 VERIFIED: YES
Provenance & Taxonomy
Rana areolata [Animal]
Ranatuerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
23-28
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus
>200 μM
MIC
PaperAntimicrobial peptides and protease inhibitors in the skin secretions of the crawfish frog, Rana areolata.
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