Peptide Database

Peptide NameCADY-2 (SEQ ID No: 8)

Function Ontology

Anticancer

Antimicrobial

Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide

Delivery / Targeting ▸ Drug delivery vehicle

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC137H206N38O23

DescriptionStandard

        GLWRALWRALWRSLWKLKWKV
    

Molecular Weight2753.34 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)5.76

Net Charge (pH 7.4) 5.55

Charge Density (pH 7.0) 0.2741

GRAVY Index-0.20

Hydrophobic Moment 0.83

Boman Index-0.01

Instability Index63.42

Aliphatic Index 116.19

Aromaticity 0.2381

Extinction Coeff. Reduced 27500.00

Extinction Coeff. Oxidized 27500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1008.26

LogP 0.44

H-bond Donors 40.0

H-bond Acceptors 29.0

Rotatable Bonds 87.0

Heavy Atoms 198.0

Ring Count 10.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0284678 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCADY

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Cell-penetrating peptide Cargo delivery

RECORD: Rec_0298272 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCADY

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anticancer

PaperSelf-assembled peptide (CADY-1) improved the clinical application of doxorubicin.; Modeling of non-covalent complexes of the cell-penetrating peptide CADY and its siRNA cargo. PMID22688249;23000699 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22688249/ PatentUS7943581B2

RECORD: Rec_0346351 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermCysteamide group

Bio-Activity Profile

Function

Drug Delivery Vehicle Cell-penetrating peptide

RECORD: Rec_0416336 VERIFIED: NO

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

FamilyCADY

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Cell-penetrating peptide

TargetHeLa; HS-68 cells

MethodCellular uptake assay