Peptide Database

Peptide NameHlf(1-47)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antiviral

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Standard StatusStandard

Sequence Length47 amino acids

Chemical FormulaC236H390N82O63S5

DescriptionStandard

        GRRRRSVQWCAVSQPEATKCFQWQRNMRKVRGPPVSCIKRDSPIQCI
    

Molecular Weight5544.46 Da

Isoelectric Point (pI)11.24

Net Charge (pH 7.0)8.72

Net Charge (pH 7.4) 8.45

Charge Density (pH 7.0) 0.1856

GRAVY Index-0.85

Hydrophobic Moment 0.60

Boman Index-0.35

Instability Index97.10

Aliphatic Index 53.83

Aromaticity 0.0638

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11250.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2405.89

LogP -27.66

H-bond Donors 90.0

H-bond Acceptors 77.0

Rotatable Bonds 183.0

Heavy Atoms 386.0

Ring Count 9.0

Amide Bonds 52.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0052636 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyLactoferrin-derived

Tax ID9606;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Entry inhibitor

TargetHepatitis B virus (Virus entry); HepaRG

Activity55 %

MethodRT-PCR

PaperCharacterization of the anti-HBV activity of HLP1-23, a human lactoferrin-derived peptide. | Florian PE, Macovei A, Lazar C, Milac AL, Sokolowska I, Darie CC, Evans RW, Roseanu A, Branza-Nichita N. | J Med Virol. 2013 | PMID:23508903 PMID23508903 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23508903/

RECORD: Rec_0182542 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide; DSSP H 34.0%, E 12.8%, T 27.7%, C 25.5% [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Antimicrobial

RECORD: Rec_0360868 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide10-26; 20-37

Bio-Activity Profile

Function

Antimicrobial Antibacterial