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MYP_053473
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Basic Information
Nigrocin-2GRa
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
21 amino acids
C86H150N24O24S2
Standard
Sequence
GLLSGILGAGKHIVCGLSGLC
Physicochemical Analysis
1968.39 Da
8.07
0.83
0.54
0.0394
1.33
0.43
0.52
23.45
148.57
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
740.48
-7.18
28.0
28.0
66.0
136.0
1.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0237146 VERIFIED: YES
Provenance & Taxonomy
Odorrana grahami [Animal]
Nigrocin
167935
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
15-21
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus
75 μg/mL
MIC
PaperAntimicrobial peptides from diverse families isolated from the skin of the Asia frog, Rana Grahami
RECORD: Rec_0244226 VERIFIED: YES
Provenance & Taxonomy
Rana grahami [Animal]
Nigrocin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
15-21
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Hemolytic
human erythrocytes
295 μM
LC50
PMID16621155 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16621155/
RECORD: Rec_0246048 VERIFIED: YES
Provenance & Taxonomy
Rana grahami [Animal]
Nigrocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans
100 μM
MIC
PMID16621155;16487561 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16621155/
RECORD: Rec_0293268 VERIFIED: YES
Provenance & Taxonomy
Odorrana grahami [Animal]
Nigrosin
167935
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
15-21
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
2.55 μM
MIC
PaperX. Xu et al. / Toxicon 47 (2006) 459-464. Two antimicrobial peptides from skin secretions of Rana grahami PMID16487561 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16487561/
RECORD: Rec_0296808 VERIFIED: YES
Provenance & Taxonomy
Odorrana grahami [Animal]
Nigrocin
167935
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
15-21
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli, B. dysenteriae
2.5-5 μg/mL
MIC
PaperAntimicrobial peptides from diverse families isolated from the skin of the Asia frog, Rana Grahami
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