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MYP_053473
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Basic Information
Nigrocin-2GRa
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
21 amino acids
C86H150N24O24S2
Standard
Sequence
GLLSGILGAGKHIVCGLSGLC
Physicochemical Analysis
1968.39 Da
8.07
0.83
0.54
0.0394
1.33
0.43
0.52
23.45
148.57
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
740.48
-7.18
28.0
28.0
66.0
136.0
1.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0070399 VERIFIED: YES
Provenance & Taxonomy
Odorrana grahami [Animal]
Nigrocin
167935
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
15-21
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli
>100 μM
MIC
PaperAntimicrobial peptides from diverse families isolated from the skin of the Asia frog, Rana Grahami
RECORD: Rec_0077056 VERIFIED: NO
Provenance & Taxonomy
Rana grahami,Huia grahami [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli, Staphylococcus aureus, Candida albicans
RECORD: Rec_0081502 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
295 μM
LC50
Paperhttps://pubmed.ncbi.nlm.nih.gov/16621155/ PMID16621155 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16621155/
RECORD: Rec_0093377 VERIFIED: YES
Provenance & Taxonomy
Odorrana andersonii [Animal]
Nigrosin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
15-21
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
2.55 μM
MIC
PaperX. Xu et al. / Toxicon 47 (2006) 459-464. Two antimicrobial peptides from skin secretions of Rana grahami PMID16487561 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16487561/
RECORD: Rec_0097711 VERIFIED: YES
Provenance & Taxonomy
Odorrana grahami [Animal]
Nigrocin
167935
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
15-21
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli
25 μM
MIC
PaperAntimicrobial peptides from diverse families isolated from the skin of the Asia frog, Rana Grahami
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