Peptide Database

Peptide NameSLAY-screened peptide P5571

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC121H165N27O29

DescriptionStandard

        LFSPYRWYYNYLHPTLSGAI
    

Molecular Weight2461.77 Da

Isoelectric Point (pI)8.44

Net Charge (pH 7.0)0.84

Net Charge (pH 7.4) 0.58

Charge Density (pH 7.0) 0.0422

GRAVY Index-0.14

Hydrophobic Moment 0.44

Boman Index0.24

Instability Index52.14

Aliphatic Index 83.00

Aromaticity 0.3000

Extinction Coeff. Reduced 11460.00

Extinction Coeff. Oxidized 11460.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 889.71

LogP -3.31

H-bond Donors 32.0

H-bond Acceptors 31.0

Rotatable Bonds 68.0

Heavy Atoms 177.0

Ring Count 10.0

Amide Bonds 20.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0054948 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/