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MYP_053380
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Basic Information
AL-11
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Cardiovascular
Hormonal / Endocrine ▸ Hormone peptide
Hormonal / Endocrine ▸ Secretory pathway peptide ▸ Secretory granule peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide precursor
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Standard
11 amino acids
C54H79N15O14
Standard
Sequence
AYGFRGPGPQL
Physicochemical Analysis
1162.30 Da
8.79
0.79
0.61
0.0723
-0.48
0.31
0.13
11.16
44.55
0.1818
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
461.96
-4.06
15.0
15.0
32.0
83.0
4.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0084932 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
AL
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Antibacterial Hormone Endocrine Neuropeptide Neuromodulator Cardiovascular Metabolic regulation Physiological regulation Myotropic Receptor modulation Immunomodulatory
Mammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour
PaperThe spectrum of endogenous human chromogranin A-derived peptides identified using a modified proteomic strategy PMID12442257 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12442257/
RECORD: Rec_0123238 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Chromogranin/secretogranin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Secretory granule peptide Neuropeptide precursor
Evidence URLhttps://www.uniprot.org/uniprotkb/CMGA_HUMAN/entry
RECORD: Rec_0163378 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
RECORD: Rec_0223654 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 18.2%, T 45.5%, C 36.4% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Cell-Cell Communication
PaperNeuroPedia: neuropeptide database and spectral library PMID21821666 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21821666/
RECORD: Rec_0303679 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
AL
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Antibacterial Hormone Endocrine Neuropeptide Neuromodulator Cardiovascular Metabolic regulation Physiological regulation Myotropic Receptor modulation Immunomodulatory
cells and noradrenergic neurons
Mammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for AL-11 (Homo sapiens): PMID 15326220,12442257 PMID15326220;12442257 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15326220/