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MYP_053315
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Basic Information
Ligand of neurotensin receptor
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Lipase inhibition
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Sensory / Food function ▸ Taste-active peptide
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Therapeutic / Biomedical activity ▸ Dermatology / Cosmetic bioactivity ▸ Skin aging modulation ▸ Anti-aging
Therapeutic / Biomedical activity ▸ Dermatology / Cosmetic bioactivity ▸ Skin aging modulation ▸ Anti-wrinkle
Therapeutic / Biomedical activity ▸ Dermatology / Cosmetic bioactivity ▸ Skin aging modulation ▸ Collagen boosting
Standard
2 amino acids
C14H18N2O4
Standard
Sequence
PY
Physicochemical Analysis
278.30 Da
5.95
-0.04
-0.10
-0.0213
-1.45
0.13
0.19
5.00
0.00
0.5000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
98.66
0.26
4.0
4.0
5.0
20.0
2.0
1.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0270603 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-inflammatory
PaperWang S., Zheng L., Zhao T., Zhang Q., Liu Y., Sun B., Su G., Zhao M.. Inhibitory effects of walnut (Juglans regia) peptides on neuroinflammation and oxidative stress in lipopolysaccharide-induced cognitive impairment mice. J. Agric. Food Chem., 68, 2381-2392, 2020.
RECORD: Rec_0290647 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
Dipeptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-aging Anti-wrinkle Collagen boosting
Normal human melanocytes (HEMn cells) (In vitro)
Immunostaining; Melanin assay
PaperPatent US 10660839 B2 PatentUS 10660839 B2
RECORD: Rec_0292737 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Phospholipase A2 Inhibitor
PaperSeo S., Lee S., Hong Y., Kim Y.. Phospholipase A2 inhibitors synthesized by two entomopathogenic bacteria, Xenorhabdus nematophila and Photorhabdus temperata subsp. temperata. Appl. env. Microbiol., 78, 3816-3823, 2012.
RECORD: Rec_0363550 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antihypertensive
PaperAHTPDB: a comprehensive platform for analysis and presentation of antihypertensive peptides PMID25392419 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25392419/
RECORD: Rec_0400994 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antidiabetic DPP-IV inhibitory
human dipeptidyl peptidase IV
PaperLan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.. Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015. PMID25577052 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25577052/
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