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MYP_053261
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Basic Information
sKFGF
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
12 amino acids
C56H97N13O15
Standard
Sequence
AAKLLPDLLAAP
Physicochemical Analysis
1192.45 Da
5.88
-0.20
-0.39
-0.0170
0.98
0.42
0.38
27.91
163.33
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
429.16
-1.39
13.0
15.0
35.0
84.0
2.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0018503 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
lactam side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
Ⓚ (3) and Ⓓ (7) are cross-linked by lactam stapling through the polar amide bond of a lactam bridge
Bio-Activity Profile
Antimicrobial Antibacterial
Enterococcus faecalis
>256 μg/mL
MIC
PaperMarco J Klein, Samuel Schmidt, Parvesh Wadhwani, Jochen Bürck, Johannes Reichert, Sergii Afonin, Marina Berditsch, Tim Schober, Roland Brock, Manfred Kansy, Anne S Ulrich. Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties. J Med Chem. 2017 Oct 12;60(19):8071-8082. Epub 2017 Sep 26. PMID28921993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28921993/
RECORD: Rec_0018982 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
lactam side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
Ⓚ (3) and Ⓓ (7) are cross-linked by lactam stapling through the polar amide bond of a lactam bridge
Bio-Activity Profile
Hemolytic
human red blood cells
20 μg/mL
Hemolysis
PaperMarco J Klein, Samuel Schmidt, Parvesh Wadhwani, Jochen Bürck, Johannes Reichert, Sergii Afonin, Marina Berditsch, Tim Schober, Roland Brock, Manfred Kansy, Anne S Ulrich. Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties. J Med Chem. 2017 Oct 12;60(19):8071-8082. Epub 2017 Sep 26. PMID28921993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28921993/
RECORD: Rec_0024994 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Enterococcus faecalis
256 μg/mL
MIC
PMID28921993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28921993/
RECORD: Rec_0028881 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
lactam side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
Ⓚ (3) and Ⓓ (7) are cross-linked by lactam stapling through the polar amide bond of a lactam bridge
Bio-Activity Profile
Hemolytic
human red blood cells
40 μg/mL
Hemolysis
PaperMarco J Klein, Samuel Schmidt, Parvesh Wadhwani, Jochen Bürck, Johannes Reichert, Sergii Afonin, Marina Berditsch, Tim Schober, Roland Brock, Manfred Kansy, Anne S Ulrich. Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties. J Med Chem. 2017 Oct 12;60(19):8071-8082. Epub 2017 Sep 26. PMID28921993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28921993/
RECORD: Rec_0077375 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
lactam side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
Ⓚ (3) and Ⓓ (7) are cross-linked by lactam stapling through the polar amide bond of a lactam bridge
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa
>256 μg/mL
MIC
PaperMarco J Klein, Samuel Schmidt, Parvesh Wadhwani, Jochen Bürck, Johannes Reichert, Sergii Afonin, Marina Berditsch, Tim Schober, Roland Brock, Manfred Kansy, Anne S Ulrich. Lactam-Stapled Cell-Penetrating Peptides: Cell Uptake and Membrane Binding Properties. J Med Chem. 2017 Oct 12;60(19):8071-8082. Epub 2017 Sep 26. PMID28921993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28921993/
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