Peptide Database

Peptide Namegrowth/differentiation factor-9

Function Ontology

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length135 amino acids

Chemical FormulaC692H1061N187O202S8

DescriptionStandard

        GQETVSSELKKPLGPASFNLSEYFRQFLLPQNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR
    

Molecular Weight15488.48 Da

Isoelectric Point (pI)7.76

Net Charge (pH 7.0)1.07

Net Charge (pH 7.4) 0.53

Charge Density (pH 7.0) 0.0079

GRAVY Index-0.51

Hydrophobic Moment 0.56

Boman Index-0.05

Instability Index47.79

Aliphatic Index 70.74

Aromaticity 0.1111

Extinction Coeff. Reduced 22920.00

Extinction Coeff. Oxidized 23295.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6223.28

LogP -59.15

H-bond Donors 219.0

H-bond Acceptors 215.0

Rotatable Bonds 495.0

Heavy Atoms 1089.0

Ring Count 33.0

Amide Bonds 144.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0275889 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsThe active peptide is predicted to be either a homodimer or a heterodimer, which cannot be disulphide linked. Predicted N-linked glycosylation of asparagine residue at position 19; predicted disulphide bond formation between cysteine residues at positions 34 and 100, 63 and 132, and 67 and 134

Bio-Activity Profile

Function

Receptor agonist Signaling peptide

TargetGrowth/differentiation factor receptors (Human)