MYP_053238
Ac-S2
Antimicrobial
Antimicrobial
▸
Antibacterial
Toxicity / Safety
▸
Blood cell toxicity
▸
Hemolysis
▸
Hemolytic
Standard
7 amino acids
C38H63N11O8
Standard
KAAKWAK
801.98 Da
10.30
2.76
2.55
0.3939
-1.03
0.63
-0.26
-12.90
42.86
0.1429
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
331.77
-1.52
12.0
11.0
27.0
57.0
2.0
6.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0119510
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The Ⓧ (position: 2 and 6) in sequence indicates (S)-α-methyl, α-pententylglycine. Ⓧ (2) and Ⓧ (6) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Hemolytic
human red blood cells
1.6 μM
Hemolysis
RECORD: Rec_0126129
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The Ⓧ (position: 2 and 6) in sequence indicates (S)-α-methyl, α-pentenylglycine. Note: the Experimental section presenst that X is (S)-α-methyl, α-pentenylglycine, while the Results section presents that X is pentenylalanine. We incline to the former representation according to previous papers published by the research group which the author belonged. Ⓧ (2) and Ⓧ (6) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Hemolytic
human red blood cells
25.0 μM
Hemolysis
RECORD: Rec_0128970
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The Ⓧ (position: 2 and 6) in sequence indicates (S)-α-methyl, α-pententylglycine. Ⓧ (2) and Ⓧ (6) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial
Antibacterial
Staphylococcus aureus ATCC 6538p
37.5 μM
MIC
RECORD: Rec_0142167
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The Ⓧ (position: 2 and 6) in sequence indicates (S)-α-methyl, α-pentenylglycine. Note: the Experimental section presenst that X is (S)-α-methyl, α-pentenylglycine, while the Results section presents that X is pentenylalanine. We incline to the former representation according to previous papers published by the research group which the author belonged. Ⓧ (2) and Ⓧ (6) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial
Antibacterial
Pseudomonas aeruginosa ATCC 27853
>100 μM
MIC
RECORD: Rec_0145838
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The Ⓧ (position: 2 and 6) in sequence indicates (S)-α-methyl, α-pententylglycine. Ⓧ (2) and Ⓧ (6) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Hemolytic
human red blood cells
6.3 μM
Hemolysis
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