Peptide Database

Peptide NameCaerin 1.1 mod 7(Caerin 1.1 [E23A,H24A])

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV

Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition

Standard StatusStandard

Sequence Length25 amino acids

Chemical FormulaC116H198N30O28

DescriptionStandard

        GLLSVLGSVAKHVLPHVVPVIAAAL
    

Molecular Weight2461.00 Da

Isoelectric Point (pI)8.76

Net Charge (pH 7.0)0.93

Net Charge (pH 7.4) 0.63

Charge Density (pH 7.0) 0.0373

GRAVY Index1.60

Hydrophobic Moment 0.47

Boman Index0.57

Instability Index32.71

Aliphatic Index 179.20

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 867.98

LogP -4.35

H-bond Donors 29.0

H-bond Acceptors 31.0

Rotatable Bonds 75.0

Heavy Atoms 174.0

Ring Count 4.0

Amide Bonds 24.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0096979 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCaerin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HIV Release inhibition

TargetHuman immunodeficiency virus (HIV) | T cells

Activity2.5 μM

MethodIC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperInhibition of HIV infection by caerin 1 antimicrobial peptides. | VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA. | Peptides. 2015 Sep;71:296-303. | DOI:10.1016/j.peptides.2015.05.004 | PMID:26026377 PMID26026377 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26026377/

RECORD: Rec_0174157 VERIFIED: YES

Provenance & Taxonomy

OrganismSythetic construct [Animal]

FamilyCaerin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHuman immunodeficiency virus (HIV):inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells

Activity2.5 μM

MethodIC50

RECORD: Rec_0308788 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCaerin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetHIV PsV