Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length487 amino acids

Chemical FormulaC2440H3868N646O686S21

DescriptionStandard

        MRENMARGPCNAPRWASLLVLVAIGTAVTAAVNPGVVVRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGHYSFYSMDIREFQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKTSGNFDLSIEGMSISADLKLGSNRTSGKPTITCSSCSSHINSVHMRISKSKVGWLIQLFHKKIESALRNKMNSQVCEKVTNSVSSELQPYFQTLPVMTKIDAVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPPFAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFFGTFLPEVAKKFPNMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAILPNSSLASLFLIGMHTTGSMEVSAESDRLVGELKLDRLLLELKHSNIGPFPVALLQDIMNYIVPILVLPRVNEKLQKGFPLPTPARVQLYNVVLQPHQNFLLFGADVVYK
    

Molecular Weight53902.09 Da

Isoelectric Point (pI)9.51

Net Charge (pH 7.0)16.62

Net Charge (pH 7.4) 15.57

Charge Density (pH 7.0) 0.0341

GRAVY Index-0.05

Hydrophobic Moment 0.70

Boman Index0.09

Instability Index40.48

Aliphatic Index 92.07

Aromaticity 0.0862

Extinction Coeff. Reduced 37360.00

Extinction Coeff. Oxidized 37610.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0128976 VERIFIED: YES

Provenance & Taxonomy

OrganismPan paniscus [Animal]

FamilyBPI/LBP

Tax ID9597

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria