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MYP_053124
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Basic Information
ACE2 (27-42)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Enzyme modulation ▸ Enzyme inhibition ▸ CPE inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
16 amino acids
C94H129N21O29
Standard
Sequence
TFLDKFNHEAEDLFYQ
Physicochemical Analysis
2017.15 Da
4.31
-3.51
-3.76
-0.2193
-0.77
0.54
-0.02
44.19
55.00
0.2500
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
830.36
-5.25
27.0
27.0
65.0
144.0
5.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0327138 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
SARS-CoV-2:Inhibition of infection in 293T/ACE2 cells
2390±200 μM
IC50
PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/
RECORD: Rec_0371352 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
ACE2-derived peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus 2
2.39 μM
IC50
PaperRationally designed ACE2-derived peptides inhibit SARS-CoV-2 PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/
RECORD: Rec_0397110 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Infection inhibition
SARS-CoV-2 | 293T/ACE2 cells
2390±200 μM
IC50
Mammalian: 7.2 h; Yeast: >20 h; E. coli: >10 h
PaperRationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2. | Larue RC, Xing E, Kenney AD, Zhang Y, Tuazon JA, Li J, Yount JS, Li PK, Sharma A. | Bioconjug Chem. 2021 Jan 20;32(1):215-223. | DOI:10.1021/acs.bioconjchem.0c00664 | PMID:33356169 PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/
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