Peptide Database

Peptide NameBeta-defensin

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length111 amino acids

Chemical FormulaC466H776N142O146S10

DescriptionStandard

        MKSLLSALMIIMFLAHLVTGNWYVRKCANKLGTCRKTCRKGEYQTDPATGKCSIGKLCCILDLKLAGQCGGADGNQAAAGTQAAGGTRAAGGTQGTGGTGATGAAATTAAP
    

Molecular Weight11024.66 Da

Isoelectric Point (pI)9.40

Net Charge (pH 7.0)7.51

Net Charge (pH 7.4) 7.13

Charge Density (pH 7.0) 0.0677

GRAVY Index0.04

Hydrophobic Moment 0.56

Boman Index0.11

Instability Index-2.52

Aliphatic Index 71.53

Aromaticity 0.0360

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8855.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4605.03

LogP -62.08

H-bond Donors 169.0

H-bond Acceptors 165.0

Rotatable Bonds 369.0

Heavy Atoms 764.0

Ring Count 8.0

Amide Bonds 118.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0101605 VERIFIED: NO

Provenance & Taxonomy

OrganismRanitomeya imitator [Animal]

FamilyDefensin

Structure & Mods

Configdisulfide-stabilized linear peptide scaffold [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin

RECORD: Rec_0351928 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyBeta-defensin; Defensin

Tax ID10116

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Non-hemolytic