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MYP_053044
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Basic Information
Temporin-Sha[K3]
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
13 amino acids
C70H115N15O14S
Standard
Sequence
FLKGIVGMLGKLF
Physicochemical Analysis
1422.82 Da
10.00
1.76
1.55
0.1352
1.43
0.51
0.55
-36.48
142.31
0.1538
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
464.56
0.45
16.0
17.0
49.0
100.0
2.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0165061 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
toxicity was observed on Keratinocyte at the concentration of 10 μM with a cell viability of 74%
10 μM
Cytotoxicity
PaperPubMed PMID: 30669255 PMID30669255 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30669255/
RECORD: Rec_0325374 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Listeria ivanovii
1.56 μM
MIC
PMID30813478 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30813478/
RECORD: Rec_0354495 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Listeria ivanovii
3.12 μM
MBC
PMID30813478 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30813478/
RECORD: Rec_0373682 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HSV Entry inhibition
HSV-1
2.5 μM
% inhibition
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperComparison of Anti-Viral Activity of Frog Skin Anti-Microbial Peptides Temporin-Sha and [K³]SHa to LL-37 and Temporin-Tb against Herpes Simplex Virus Type 1. | Roy M, Lebeau L, Chessa C, Damour A, Ladram A, Oury B, Boutolleau D, Bodet C, Lévêque N. | Viruses. 2019 Jan 18;11(1):77. | DOI:10.3390/v11010077 | PMID:30669255 PMID30669255 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30669255/
RECORD: Rec_0405085 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HSV Entry inhibition
HSV-1
5 μM
% inhibition
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperComparison of Anti-Viral Activity of Frog Skin Anti-Microbial Peptides Temporin-Sha and [K³]SHa to LL-37 and Temporin-Tb against Herpes Simplex Virus Type 1. | Roy M, Lebeau L, Chessa C, Damour A, Ladram A, Oury B, Boutolleau D, Bodet C, Lévêque N. | Viruses. 2019 Jan 18;11(1):77. | DOI:10.3390/v11010077 | PMID:30669255 PMID30669255 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30669255/
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