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MYP_053043
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Basic Information
Histatin5
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
24 amino acids
C133H195N51O33
Standard
Sequence
DSHAKRHHGYKRKFHEKHHSHRGY
Physicochemical Analysis
3036.29 Da
10.28
5.37
4.80
0.2237
-2.45
0.38
-0.63
37.87
4.17
0.1250
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1378.68
-14.64
51.0
45.0
102.0
217.0
10.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0392317 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Histatin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0403656 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Histatin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
Streptococcus mutans U159
234 μg/mL
MIC
PMID34417532;33740624;31417503;11302797;3286634 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34417532/
RECORD: Rec_0407229 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Histatin
9606
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
allo-residue reported
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
Cryptococcus neoformans CN2 or amphotericin B resistant
3.71-3.72 μM
ED50
PaperHistatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans.
RECORD: Rec_0411157 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
PaperPatent US 10464977 B2 Evidence URLhttps://patents.google.com/patent/US10464977B2/en PatentUS 10464977 B2
RECORD: Rec_0413581 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Histatin-derived
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antifungal
Candida albicans CAF4-2
60 μM
Biofilm Dry Weight (mg)
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