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MYP_053043
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Basic Information
Histatin5
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
24 amino acids
C133H195N51O33
Standard
Sequence
DSHAKRHHGYKRKFHEKHHSHRGY
Physicochemical Analysis
3036.29 Da
10.28
5.37
4.80
0.2237
-2.45
0.38
-0.63
37.87
4.17
0.1250
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1378.68
-14.64
51.0
45.0
102.0
217.0
10.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0003148 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Histatin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
Candida albicans ATCC10231
8.5 μg/mL
IC50
PMID34417532;33740624;31417503;11302797;3286634 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34417532/
RECORD: Rec_0007552 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Histatin
9606
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
allo-residue reported
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
A.actinomycetemcomitans
>100 μM
ED50
PaperHistatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans.
RECORD: Rec_0014185 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Histatin-derived
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antifungal
Candida albicans ATCC SC5314
0.8 nmol/cm2
Total countable CFUs
RECORD: Rec_0014615 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Histatin
9606
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
allo-residue reported
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
C. glabrata or fluconazole resistant
38.7-85.3 μM
ED50
PaperHistatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans.
RECORD: Rec_0023503 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
D-Hst5
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic Antileishmanial
Leishmania pifanoi MHOM/VE/60/Ltrod (amastigote axenic)
2.1±0.1 μM
LC50; MTT assay
PMID18230684 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18230684/
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