Peptide Database

Peptide NameUnnamed

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV

Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV

Antiviral ▸ Anti-HIV

Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition

Antiviral ▸ Virucidal activity

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC87H124N20O22S

DescriptionStandard

        SWLRDIWDWICEVL
    

Molecular Weight1834.10 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-2.54

Net Charge (pH 7.4) -2.77

Charge Density (pH 7.0) -0.1818

GRAVY Index0.34

Hydrophobic Moment 0.75

Boman Index0.24

Instability Index31.86

Aliphatic Index 132.14

Aromaticity 0.2143

Extinction Coeff. Reduced 16500.00

Extinction Coeff. Oxidized 16500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 683.02

LogP -0.29

H-bond Donors 26.0

H-bond Acceptors 21.0

Rotatable Bonds 55.0

Heavy Atoms 130.0

Ring Count 6.0

Amide Bonds 13.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0410345 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HCV Release inhibition

TargetHepatitis C virus (HCV) | Huh-7.5.1 cells

Activity11.3 μM

MethodIC50

Half-LifeMammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h

PaperA virocidal amphipathic {alpha}-helical peptide that inhibits hepatitis C virus infection in vitro. | Cheng G, Montero A, Gastaminza P, Whitten-Bauer C, Wieland SF, Isogawa M, Fredericksen B, Selvarajah S, Gallay PA, Ghadiri MR, Chisari FV. | Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3088-93. | DOI:10.1073/pnas.0712380105 | PMID:18287023 PMID18287023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18287023/

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