Peptide Database

Peptide NameCholecystokinin-58

Function Ontology

Gastrointestinal bioactivity

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length58 amino acids

Chemical FormulaC286H460N92O85S3

DescriptionStandard

        AVQRTDGESRAHLGALLARYIQQARKAPSGRMSIIKNLQNLDPSHRISDRDYMGWMDF
    

Molecular Weight6643.47 Da

Isoelectric Point (pI)9.97

Net Charge (pH 7.0)2.97

Net Charge (pH 7.4) 2.67

Charge Density (pH 7.0) 0.0513

GRAVY Index-0.69

Hydrophobic Moment 0.67

Boman Index-0.18

Instability Index47.14

Aliphatic Index 75.86

Aromaticity 0.0690

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2907.11

LogP -31.69

H-bond Donors 103.0

H-bond Acceptors 93.0

Rotatable Bonds 224.0

Heavy Atoms 466.0

Ring Count 9.0

Amide Bonds 63.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0142477 VERIFIED: NO

Provenance & Taxonomy

OrganismMacaca fascicularis [Animal]

FamilyGastrin/cholecystokinin

Tax ID9541

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Other ModsTyr52 Sulfotyrosine

Bio-Activity Profile

Function

Hormone Gastrointestinal Neuropeptide

RECORD: Rec_0194032 VERIFIED: YES

Provenance & Taxonomy

OrganismMacaca fascicularis [Animal]

FamilyCholecystokinin

Tax ID9541

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

C-TermAmidation

Other Mods52:Sulfotyrosine

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Myotropic Receptor modulation

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0389460 VERIFIED: YES

Provenance & Taxonomy

OrganismMacaca fascicularis [Animal]

FamilyCholecystokinin

Tax ID9541

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

C-TermAmidation

Other Mods52:Sulfotyrosine

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Myotropic Receptor modulation

TargetCCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour