Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2322H3740N592O670S18

DescriptionStandard

        MFLCCWLALVALIPMTSGTNPGVEVKLTEKGLEYGRQLGMASIQQKLKTIKVPDISGSQEVSPIGKVKYSLSNMQIVDVGLPKSALDLVPGTGVRLSIGNAFIQLHGNWRVKYIKIIKDSGSFDLNVNDLTITTSIAIKSDETGRPVVSSVSCAATVGSASIKFHGGASWLYNLFKNFIDKALRNALQKQICPLVADAVSDLNPQLKTLNVVAKVDQYAEIEYSMVSSPTVSSSSIDFSLKGEFYNIGKHQEPPFSPAAFSLPPQVNNMLYIGVSVFTTNSAAFVYNTAGALSLYITDDMIPQGSPIRLNTRTFGAFIPQIARRFPGLMMKLLVKTVKSPVITFQPNNVTVQATGTVTAYAIQANTTLSPLFVLNLETSVSVQLFVSEMRLAGAVTLNKMDLTLGTSYVGEFQVKSLNSILQMVLKVVVIPKVNVQLAKGYPLPTLGKMKLVNTQLQVLKDYMLIGTDVQFIG
    

Molecular Weight51247.27 Da

Isoelectric Point (pI)9.35

Net Charge (pH 7.0)11.73

Net Charge (pH 7.4) 11.20

Charge Density (pH 7.0) 0.0248

GRAVY Index0.25

Hydrophobic Moment 0.77

Boman Index0.18

Instability Index28.36

Aliphatic Index 105.86

Aromaticity 0.0782

Extinction Coeff. Reduced 37360.00

Extinction Coeff. Oxidized 37610.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0365606 VERIFIED: NO

Provenance & Taxonomy

OrganismSander lucioperca [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence