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MYP_052850
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Apoptosis induction
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Immune modulation ▸ Immunostimulatory activity
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Metabolic ▸ Lipid metabolism ▸ Cholesterol-lowering
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
6 amino acids
C27H43N7O8
Standard
Sequence
PGPIPN
Physicochemical Analysis
593.67 Da
5.96
-0.04
-0.10
-0.0069
-0.70
0.29
0.24
3.53
65.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
220.34
-2.19
6.0
8.0
13.0
42.0
3.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001796 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperWang W., Gu F., Wei C., Tang Y., Zheng X., Ren M., Qin Y.. PGPIPN, a therapeutic hexapeptide, suppressed human ovarian cancer growth by targeting BCL2. PLoS ONE, 8, e60701, 2013.
RECORD: Rec_0028914 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer Cytotoxic Pro-apoptotic
Ovarian cancer cells
PaperBioactive Hexapeptide Reduced the Resistance of Ovarian Cancer Cells to DDP by Affecting HSF1-HSP70 Signaling Pathway | Ruowen, G. et al. | DOI: 10.7150/jca.62285 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0059649 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive Nitric oxide-modulating
Angiotensin-converting enzyme (ACE)
IC50
PaperCharacterization of casein-derived peptide bioactivity: Differential effects on angiotensin-converting enzyme inhibition and cytokine and nitric oxide production | Adams, C. et al. | DOI: 10.3168/jds.2019-17976 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0108945 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Phosphorylation
Bio-Activity Profile
Immunomodulatory Hypocholesterolemic Hepatoprotective Pro-apoptotic
Mice
Superoxide scavenging assay
PaperMilk-derived hexapeptide PGPIPN prevents and attenuates acute alcoholic liver injury in mice by reducing endoplasmic reticulum stress | Xu, Q. et al. | DOI: 10.3892/ijmm.2020.4643 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0193661 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer Cytotoxic Pro-apoptotic
Ovarian cancer cells
Cell proliferation assay
PaperPGPIPN, a Therapeutic Hexapeptide, Suppressed Human Ovarian Cancer Growth by Targeting BCL2 | Wang, W. et al. | DOI: 10.1371/journal.pone.0060701 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
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