Peptide Database

Peptide NameSLAY-screened peptide P347

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC115H177N29O24

DescriptionStandard

        VPFLPGIWVLPRPVRIASFAN
    

Molecular Weight2349.82 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)1.73

Net Charge (pH 7.4) 1.52

Charge Density (pH 7.0) 0.0826

GRAVY Index0.83

Hydrophobic Moment 0.57

Boman Index0.36

Instability Index52.88

Aliphatic Index 125.24

Aromaticity 0.1429

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 813.07

LogP -2.45

H-bond Donors 27.0

H-bond Acceptors 26.0

Rotatable Bonds 65.0

Heavy Atoms 168.0

Ring Count 8.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0112442 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/