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MYP_052653
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Basic Information
fragment of human alpha s1-casein
Anticancer
Anticancer ▸ Anti-breast cancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid receptor ligand
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
5 amino acids
C33H43N5O7
Standard
Sequence
YVPFP
Physicochemical Analysis
621.72 Da
5.52
-0.24
-0.45
-0.0482
0.50
0.13
0.55
123.56
58.00
0.4000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
182.37
1.20
5.0
7.0
12.0
45.0
4.0
4.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0032997 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Casomorphin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid
opioid receptor
PaperKampa M., Loukas S., Hatzoglou A., Martin P., Castinas E.. Identification of a novel opioid peptide (Tyr-Val-Pro-Phe-Pro) derived from human alpha s1-casein (alpha s1-casomorphin and alpha s1-casomorphin amide). Biochem. J., 319, 903-908, 1996.
RECORD: Rec_0035431 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid
RECORD: Rec_0149302 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Casein-derived peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Neuropeptide
RECORD: Rec_0186355 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Casomorphin
9606
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Opioid receptor ligand Anti-breast cancer Cell-proliferative
Cell proliferation assay
PaperIdentification of a novel opioid peptide (Tyr-Val-Pro-Phe-Pro) derived from human α S1 casein (α S1-casomorphin, and α S1-casomorphin amide) | Kampa, M. et al. | DOI: 10.1042/bj3190903 Evidence URLhttps://www.uniprot.org/uniprotkb/P47710/entry
RECORD: Rec_0228101 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Casein-derived peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
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