Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length446 amino acids

Chemical FormulaC2198H3493N557O659S22

DescriptionStandard

        MDLEITFYYQGSGQQIEIDSIQQKLKTIKLMDMSGTEKLDIGKVEYSITGMQIVNLGLPKSAVGFVPGTGILLSVANAYITLRGNWRVKYLRRDTGSFDLAVNELAVSSNIEVKSDGTGHPTVSMTNCAATVGSVKVKLHGGASWLYSLFSSFMNTALHKALQKQICRSVTDSFADMNSFLKSLNAKVDQYAEIEYTMVESPVISNTMIELGFKGEFYNIGQHKEPPFSPKPFSLPSQETNMLYMGVSAFSINSASFVYHRAGALRLYITDDMIPSDSSNRLNTKTFGTFIPQIEKTYPGLMMKLLFETVKEPLITCEPNNMTIQASGMMTAFAIQSDGTLSPLFVLNLEGSVSTNIYVSGLKLAGHVTLDKIHMSLAKSYVGSFQVTSLDDIFTTVLKVAVIPKVNAQLKEGYSLPATVKMQLQKTQIQVLKDYVLIGTDVQVTA
    

Molecular Weight48971.01 Da

Isoelectric Point (pI)7.05

Net Charge (pH 7.0)0.11

Net Charge (pH 7.4) -0.62

Charge Density (pH 7.0) 0.0002

GRAVY Index0.05

Hydrophobic Moment 0.71

Boman Index0.13

Instability Index35.33

Aliphatic Index 93.30

Aromaticity 0.0874

Extinction Coeff. Reduced 36330.00

Extinction Coeff. Oxidized 36455.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0344198 VERIFIED: NO

Provenance & Taxonomy

OrganismLabeo rohita [Bacterium]

FamilyBPI

Tax ID84645

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence