Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length507 amino acids

Chemical FormulaC2561H4012N658O739S18

DescriptionStandard

        MQTKKVQVFWGCFLLWNLHISSSRTIYPGIKARITQQALDYGVQVGMKMIEQMVKEKNIPDIKGSESLEFLKIDYVNYNFSNIKVNDLSFPNTSLAFVAGEGIKALTNHGTVNISTHWEIGSPLFQDIGEADLFLSGVYFTGIILLTRNDFGHPALKLQDCHAQVSHAHVSFSGGLSVLYNSFAEPMEKPILRNINEMLCPIISNEVEALNINLTALEVLTKIDNYTLLDCSLISSPEITEHCLDLNLKGAFYPLENLTDPPFSPVPFVLPALRDSMLYIGISEYFFRSASFAHFTAGAFSVTLSTKEISHQFVQNSQGLGNVLSRIAEIYILSQPFILKIMATEPPVINLQPGNFTLDIPASIIMLTQPENSTMQHIVSMDFVASTSVGLAILGQRLICSLSLNRFRLSLPESNRSDIKVLRFENILSSILHFGVLPLANTKLQQGFPLPNPHKISFVNSDIEVLEGFLLISTDLKHEMSSKQQPSSHSWGSLNLISGRWREKPAS
    

Molecular Weight56420.38 Da

Isoelectric Point (pI)5.93

Net Charge (pH 7.0)-8.19

Net Charge (pH 7.4) -9.36

Charge Density (pH 7.0) -0.0162

GRAVY Index0.11

Hydrophobic Moment 0.76

Boman Index0.16

Instability Index45.32

Aliphatic Index 104.02

Aromaticity 0.0907

Extinction Coeff. Reduced 43890.00

Extinction Coeff. Oxidized 44265.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0152916 VERIFIED: NO

Provenance & Taxonomy

OrganismCastor canadensis [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria