Peptide Database

Peptide NameSLAY-screened peptide P2042

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC90H150N30O30S

DescriptionStandard

        VITTFSNKTSSGHRPTCTAR
    

Molecular Weight2164.40 Da

Isoelectric Point (pI)10.86

Net Charge (pH 7.0)2.81

Net Charge (pH 7.4) 2.53

Charge Density (pH 7.0) 0.1405

GRAVY Index-0.58

Hydrophobic Moment 0.40

Boman Index-0.17

Instability Index63.07

Aliphatic Index 39.00

Aromaticity 0.0500

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 990.86

LogP -15.98

H-bond Donors 38.0

H-bond Acceptors 35.0

Rotatable Bonds 68.0

Heavy Atoms 151.0

Ring Count 3.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0261861 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/