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MYP_052560
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Basic Information
Peptide 75(710-725)[Δ1-5]
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Standard
11 amino acids
C75H113N13O15
Standard
Sequence
KWEYVLLLFLL
Physicochemical Analysis
1436.78 Da
6.00
-0.24
-0.45
-0.0217
1.49
0.13
0.58
9.09
203.64
0.2727
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
453.66
4.04
16.0
15.0
45.0
103.0
4.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0081997 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 20156485 PMID20156485 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20156485/
RECORD: Rec_0119150 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
hepatitis C virus
78 %
Inhibition
PaperPubMed PMID: 20156485 PMID20156485 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20156485/
RECORD: Rec_0124365 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HCV Entry inhibition
Hepatitis C virus(HCVpp) | hepatoma cells
50 μM
% inhibition
Mammalian: 1.3 h; Yeast: 3 min; E. coli: 2 min
PaperA peptide derived from hepatitis C virus E2 envelope protein inhibits a post-binding step in HCV entry. | Liu R, Tewari M, Kong R, Zhang R, Ingravallo P, Ralston R. | Antiviral Res. 2010 May;86(2):172-9. | DOI:10.1016/j.antiviral.2010.02.316 | PMID:20156485 PMID20156485 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20156485/
RECORD: Rec_0215231 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Hepatitis C virus (HCV) PsV
70-80 % Inhibition
Inhibition
PMID20156485 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20156485/
RECORD: Rec_0218392 VERIFIED: YES
Provenance & Taxonomy
Hepatitis C virus [Virus]
Virus-derived peptide
3052230;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Hepatitis C virus (Virus entry); Huh7
78 %
Luciferase assay
PaperA peptide derived from hepatitis C virus E2 envelope protein inhibits a post-binding step in HCV entry. | Liu R, Tewari M, Kong R, Zhang R, Ingravallo P, Ralston R. | Antiviral Res. 2010 | PMID:20156485 PMID20156485 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20156485/
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