Peptide Database

Peptide NameVirgicin

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length44 amino acids

Chemical FormulaC199H305N53O69S6

DescriptionStandard

        MESLESVISNVSDEELAEVSGGVGCGWICTHTLDCPGTRWFNCC
    

Molecular Weight4736.25 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-6.45

Net Charge (pH 7.4) -6.79

Charge Density (pH 7.0) -0.1465

GRAVY Index0.12

Hydrophobic Moment 0.50

Boman Index0.17

Instability Index50.12

Aliphatic Index 72.95

Aromaticity 0.0682

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11250.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1937.11

LogP -22.77

H-bond Donors 72.0

H-bond Acceptors 70.0

Rotatable Bonds 151.0

Heavy Atoms 327.0

Ring Count 7.0

Amide Bonds 45.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0092550 VERIFIED: YES

Provenance & Taxonomy

OrganismVirgibacillus sp. strain AK90 [Bacterium]

FamilyBacteriocin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive

TargetStaphylococcus aureus MTCC 1430

RECORD: Rec_0125739 VERIFIED: YES

Provenance & Taxonomy

OrganismVirgibacillus sp. strain AK90 [Bacterium]

FamilyBacteriocin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hemolytic

TargetRabbit blood

Activity80 μM

MethodHemolysis

RECORD: Rec_0157114 VERIFIED: YES

Provenance & Taxonomy

OrganismVirgibacillus sp. strain AK90 [Bacterium]

FamilyBacteriocin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive

TargetBacillus subtilis

RECORD: Rec_0276407 VERIFIED: YES

Provenance & Taxonomy

OrganismVirgibacillus sp. strain AK90 [Bacterium]

FamilyBacteriocin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive

TargetMicrococcus luteus MTCC 106

RECORD: Rec_0421079 VERIFIED: NO

Provenance & Taxonomy

OrganismVirgibacillus dokdonensis [Bacterium]

FamilyLantibiotic

Structure & Mods

Configlinear lantibiotic precursor [Linear]

Chiralitypost-translationally modified ribosomal peptide [Modified]

Other ModsLantibiotic-family precursor annotation suggests post-translational lanthionine/methyllanthionine thioether crosslinks in the mature peptide

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic

TargetGram-positive bacteria

MethodQualitative functional evidence