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MYP_052514
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Basic Information
Tachystatin B2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
42 amino acids
C216H323N67O56S6
Standard
Sequence
YITCLFRGARCRVYSGRSCCFGYYCRRDFPGSIFGTCSRRNF
Physicochemical Analysis
4946.68 Da
9.61
6.70
6.40
0.1595
-0.20
0.61
-0.14
59.64
37.14
0.2143
5960.00
6335.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2025.52
-22.47
84.0
69.0
155.0
345.0
10.0
42.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0130292 VERIFIED: NO
Provenance & Taxonomy
Arthropoda [Animal]
6656
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0154717 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0214626 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
Tachystatin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
100 microg/ml )
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Candida albicans
PMID10473569 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10473569/
RECORD: Rec_0242531 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal
Staphylococcus aureus
7.4 μg/mL
IC50
PaperPubMed PMID: 10473569 | PubMed PMID: 17394123 PMID10473569;17394123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10473569/
RECORD: Rec_0303535 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
4-20; 11-25; 19-37
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Host defense
PaperPDB 2DCW structural record; NMR; chain A; residues 1-42
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