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MYP_052427
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Basic Information
ACE2 (79-85)(SAP3)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
7 amino acids
C39H62N8O10S
Standard
Sequence
LAQMYPL
Physicochemical Analysis
835.02 Da
5.52
-0.24
-0.45
-0.0344
0.70
0.24
0.42
60.03
125.71
0.1429
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
292.45
-0.11
9.0
11.0
24.0
58.0
2.0
7.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0021861 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
SARS-CoV-2:Inhibition of infection in 293T/ACE2 cells
7500 μM
IC50
PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/
RECORD: Rec_0049617 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
ACE2-derived peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus 2
7.5 μM
IC50
PaperRationally designed ACE2-derived peptides inhibit SARS-CoV-2 PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/
RECORD: Rec_0163133 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Infection inhibition
SARS-CoV-2 | 293T/ACE2 cells
7500 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperRationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2. | Larue RC, Xing E, Kenney AD, Zhang Y, Tuazon JA, Li J, Yount JS, Li PK, Sharma A. | Bioconjug Chem. 2021 Jan 20;32(1):215-223. | DOI:10.1021/acs.bioconjchem.0c00664 | PMID:33356169 PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/
RECORD: Rec_0196447 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
Virus
PMID33356169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33356169/