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MYP_052413
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Basic Information
GGN6
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
24 amino acids
C125H201N27O29S2
Standard
Sequence
FLPLLAGLAANFLPTIICKISYKC
Physicochemical Analysis
2610.23 Da
8.86
1.74
1.50
0.0724
1.28
0.50
0.47
15.83
142.50
0.1250
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
870.86
-2.58
31.0
33.0
81.0
183.0
5.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0003187 VERIFIED: YES
Provenance & Taxonomy
Glandirana rugosa [Animal]
Gaegurin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
18-24
Bio-Activity Profile
Anticancer Cytotoxic
MCF-7
4.88 μg/mL
IC50
PaperIn vitro activities of native and designed peptide antibiotics against drug sensitive and resistant tumor cell lines PMID14499271 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14499271/
RECORD: Rec_0009264 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
RECORD: Rec_0013987 VERIFIED: YES
Provenance & Taxonomy
Rana rugosa [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Antiparasitic
Candida albicans
50 μg/mL
MIC
PaperAntimicrobial peptides from the skin of a Korean frog, Rana rugosa.
RECORD: Rec_0018909 VERIFIED: NO
Provenance & Taxonomy
Rana rugosa [Animal]
Structure & Mods
linear disulfide-stabilized peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiparasitic
RECORD: Rec_0022853 VERIFIED: YES
Provenance & Taxonomy
Glandirana rugosa [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Micrococcus luteus
2.5 μg/mL
MIC
PaperAntimicrobial peptides from the skin of a Korean frog, Rana rugosa. Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-954. doi: 10.1006/bbrc.1994.2757. PMID: 7999137. PMID7999137 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7999137/
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