Peptide Database

Peptide NamegH493-512(derived from HSV-1 H glycoprotein)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC98H155N25O28

DescriptionStandard

        AAHLIDALYAEFLGGRVLTT
    

Molecular Weight2131.43 Da

Isoelectric Point (pI)5.32

Net Charge (pH 7.0)-1.11

Net Charge (pH 7.4) -1.36

Charge Density (pH 7.0) -0.0557

GRAVY Index0.79

Hydrophobic Moment 0.34

Boman Index0.35

Instability Index23.27

Aliphatic Index 132.00

Aromaticity 0.1000

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 842.09

LogP -5.64

H-bond Donors 30.0

H-bond Acceptors 28.0

Rotatable Bonds 67.0

Heavy Atoms 151.0

Ring Count 3.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0140891 VERIFIED: YES

Provenance & Taxonomy

OrganismHuman alphaherpesvirus 1 [Virus]

FamilyVirus-derived peptide

Tax ID10298;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Entry inhibitor

TargetHerpes simplex virus 1 (Virus entry); Vero

Activity250 μM

MethodPlaque assay

PaperPeptides containing membrane-interacting motifs inhibit herpes simplex virus type 1 infectivity. | Galdiero S, Falanga A, Vitiello M, D'Isanto M, Cantisani M, Kampanaraki A, Benedetti E, Browne H, Galdiero M. | Peptides. 2008 | PMID:18572274 PMID18572274 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18572274/

RECORD: Rec_0173019 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide; DSSP H 35.0%, E 0.0%, T 25.0%, C 40.0% [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Antimicrobial

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