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MYP_052035
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Basic Information
Brevinin-2HS2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
33 amino acids
C142H253N39O45S
Standard
Sequence
SLLGTVKDLLIGAGKSAAQSVLKGLSGKLSKDC
Physicochemical Analysis
3258.83 Da
9.52
2.45
2.22
0.0742
0.32
0.54
0.13
4.13
121.21
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1363.69
-16.06
49.0
49.0
117.0
227.0
0.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0264102 VERIFIED: YES
Provenance & Taxonomy
Rana schmackeri [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID18423796 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18423796/
RECORD: Rec_0278763 VERIFIED: YES
Provenance & Taxonomy
Odorrana hainanensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0307417 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Huia schmackeri [Synthetic]
Brevinin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Toxicity
Poor hemolysis
300 μM
LC50
PaperNovel brevinins from Chinese piebald odorous frog (Huia schmackeri) skin deduced from cloned biosynthetic precursors
RECORD: Rec_0364972 VERIFIED: YES
Provenance & Taxonomy
Amphibia [Animal]
Brevinin
8292
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID18423796 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18423796/
RECORD: Rec_0412033 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Antifungal Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
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