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MYP_051919
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Basic Information
UL54(1223-1242)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HCMV
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Standard
20 amino acids
C106H165N31O27S2
Standard
Sequence
RRLHLEPAFLPYSVKAHECC
Physicochemical Analysis
2369.77 Da
8.06
0.92
0.58
0.0459
-0.23
0.25
-0.06
83.31
83.00
0.1000
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
920.88
-6.18
34.0
32.0
73.0
166.0
6.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0055007 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
human cytomegalovirus(HCMV):inhibition of phyical interaction between UL54 and UL44
20 μM
IC50
PaperPubMed PMID: 12857903 PMID12857903 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12857903/
RECORD: Rec_0065675 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0230080 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HCMV
Human cytomegalovirus(HCMV)
20 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperInhibition of human cytomegalovirus DNA polymerase by C-terminal peptides from the UL54 subunit. | Loregian A, Rigatti R, Murphy M, Schievano E, Palu G, Marsden HS. | J Virol. 2003 Aug;77(15):8336-44. | DOI:10.1128/jvi.77.15.8336-8344.2003 | PMID:12857903 PMID12857903 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12857903/
RECORD: Rec_0331926 VERIFIED: YES
Provenance & Taxonomy
Human betaherpesvirus 5 [Virus]
Virus-derived peptide
10359;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Replication inhibitor
Human cytomegalovirus (Disrupt UL54/UL44 interaction); Sf9
20 μM
ELISA
PaperInhibition of human cytomegalovirus DNA polymerase by C-terminal peptides from the UL54 subunit. | Loregian A, Rigatti R, Murphy M, Schievano E, Palu G, Marsden HS. | J Virol. 2003 | PMID:12857903 PMID12857903 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12857903/
RECORD: Rec_0397523 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 12857903 PMID12857903 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12857903/