Peptide Database

Peptide NameNPP

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide precursor

Standard StatusStandard

Sequence Length76 amino acids

Chemical FormulaC362H558N108O118S5

DescriptionStandard

        QCWESSRCADLSSEDGVLECIKACKTDLSAESPVFPGNGHLQPLSESIRKYVMTHFRWNKFGRRNSTGNDGSNTGY
    

Molecular Weight8471.28 Da

Isoelectric Point (pI)6.90

Net Charge (pH 7.0)-0.09

Net Charge (pH 7.4) -0.48

Charge Density (pH 7.0) -0.0012

GRAVY Index-0.75

Hydrophobic Moment 0.65

Boman Index-0.13

Instability Index72.82

Aliphatic Index 51.32

Aromaticity 0.0921

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14230.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3682.98

LogP -47.07

H-bond Donors 133.0

H-bond Acceptors 125.0

Rotatable Bonds 279.0

Heavy Atoms 593.0

Ring Count 14.0

Amide Bonds 82.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0170885 VERIFIED: YES

Provenance & Taxonomy

OrganismXenopus laevis [Animal]

FamilyNPP

Tax ID8355

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Other Mods61:Phenylalanine amide; 65:N-linked (GlcNAc...) asparagine

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0173518 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0308036 VERIFIED: NO

Provenance & Taxonomy

OrganismXenopus laevis [Animal]

FamilyPOMC

Tax ID8355

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPyroglutamate

Other ModsPhe61 Amidation

Bio-Activity Profile

Function

Hormone precursor Neuropeptide precursor