Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length503 amino acids

Chemical FormulaC2500H3988N682O692S14

DescriptionStandard

        MMELLLDIKAVRKTVQQWHRRAARMRAQSLAVACGALALCLALTDATNPGFVVRITQAGLDYAHQHGIAILEKELARLKLPDISGDFRFLGKVYYQISNLDLRTFHLPHSRISLVPNVGLQVSISNAFAELNGNWRVKYGLIRSSGSFNLKVENIYIRIDLRLGSDSSGKPTVDTSSCSTRISKVHVHFSGKLSLLYNLFKKAVESRLRKALEGKVCDNVAKAVRNELQPYAQTLPVTARIDAMTGIDYALVASPTATARSLDTGLKGEFFSLAHRSTVPFPPLPLGLPPDHERMVYFGASSYFFNTASFAYHSAGALVFEISDTMIPGGADFHLNTSTFSAFIPQLETMYPKLPMKFRLSTRSAPFLSIGPGGFSLQPVVDVQAFAVLPNATLAPLFLLSLTTNVSAVVDVTSGHIVGSLTVGRIKLSLKRSDVGAFQVRMLQSIMNIVASKILLPRLNARLGEGFPLPLPDRIQLSNILVQFHKNFLLLGADVQFQPQIGK
    

Molecular Weight55119.47 Da

Isoelectric Point (pI)9.84

Net Charge (pH 7.0)19.62

Net Charge (pH 7.4) 18.60

Charge Density (pH 7.0) 0.0390

GRAVY Index0.16

Hydrophobic Moment 0.79

Boman Index0.12

Instability Index33.35

Aliphatic Index 103.74

Aromaticity 0.0855

Extinction Coeff. Reduced 28880.00

Extinction Coeff. Oxidized 29130.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0248266 VERIFIED: NO

Provenance & Taxonomy

OrganismPatagioenas fasciata monilis [Animal]

FamilyBPI/LBP

Tax ID372326

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria