Peptide Database

Peptide NameSecukinumab

Function Ontology

Immunology ▸ Cytokine / receptor signaling modulation ▸ IL-17A inhibition

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Immunology ▸ Inflammation modulation ▸ Anti-inflammatory

Standard StatusStandard

Sequence Length231 amino acids

Chemical FormulaC1130H1724N296O344S7

DescriptionStandard

        EVQLVESGGGLVQPGGSLRLSCAASGFTFSNYWMNWVRQAPGKGLEWVAAINQDGSEKYYVGSVKGRFISRDNAKNSLYLQMNSLRVEDTAVYYCVRDYYDILTDYYIHYWYFDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK
    

Molecular Weight25184.01 Da

Isoelectric Point (pI)8.53

Net Charge (pH 7.0)3.05

Net Charge (pH 7.4) 2.60

Charge Density (pH 7.0) 0.0132

GRAVY Index-0.19

Hydrophobic Moment 0.61

Boman Index0.08

Instability Index46.36

Aliphatic Index 76.28

Aromaticity 0.1212

Extinction Coeff. Reduced 55350.00

Extinction Coeff. Oxidized 55600.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0150381 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyMonoclonal antibody

Tax ID9606

Structure & Mods

Configlinear multidomain protein biologic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Immunomodulatory Anti-inflammatory IL-17A inhibitor