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MYP_051463
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Basic Information
Beta-defensin 130B
Antimicrobial
Antimicrobial ▸ Antibiotic activity
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
79 amino acids
C394H655N105O103S7
Standard
Sequence
MKLHSLISVLLLFVTLIPKGKTGVIPGQKQCIALKGVCRDKLCSTLDDTIGICNEGKKCCRRWWILEPYPTPVPKGKSP
Physicochemical Analysis
8735.51 Da
9.47
7.53
7.15
0.0953
0.06
0.71
0.07
26.69
103.54
0.0506
12490.00
12865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3295.82
-25.29
119.0
119.0
289.0
609.0
14.0
81.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0094038 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Beta-defensin; Defensin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond; sites not specified
Bio-Activity Profile
Antimicrobial Defensin Antiparasitic Antiplasmodial Non-hemolytic
PMID16421571;28181499 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16421571/
RECORD: Rec_0197640 VERIFIED: NO
Provenance & Taxonomy
Pan troglodytes [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Non-hemolytic Non-ribosomal
Evidence URLhttps://www.uniprot.org/uniprotkb/A0A2J8Q047/entry
RECORD: Rec_0211409 VERIFIED: NO
Provenance & Taxonomy
Pan troglodytes [Animal]
Defensin
9598
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiotic Antimicrobial Defensin Non-hemolytic Non-ribosomal
Qualitative functional evidence
PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/; https://www.uniprot.org/uniprotkb/Q30KJ9/entry; https://bblserver.org.in/ampdb/
RECORD: Rec_0329424 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Evidence URLhttps://camp.bicnirrh.res.in/seqDisp.php?id=CAMPSQ6959
RECORD: Rec_0332769 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Beta-defensin; Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Defensin Antiparasitic Antiplasmodial Non-hemolytic
No Target Organism Found
PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865;16421571;28181499 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/