Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length472 amino acids

Chemical FormulaC2341H3754N590O673S14

DescriptionStandard

        MILSWCLFILALTSSTTLSTNPGVEVRLTNKGLDYGRQLGIAYVQQELRNVKIPDFSGTERVVVGKVKYCLSKIHVVNVGLPRSAIDLVPGSGVKLTIGDAFISMQGNWKIKYLVLKDSGSFDLNVNGLTITTSIAVRSDETGRPTVSVTSCAASVGSAKIKFHGGASWLYDLFTRFIDKALRDALQKQICPLVTKAVEALVPQLKTLNVLAKVDKYAEIEYSMVSSPAVSTSSIDLSLKGEFYNIGKHQEPPFSPTALSLPPQTDNMLYIALSAFTFNSAAFVYNNAKVLSIYITDDMVPKSSPFRLNTKTFGALIPQIAKQFPGLMIKLLLKTEENPQINFKPKNATLQTNATITAYAIQLNGTLSPLFVLNVESSISTQVFVVGMKIAGSLSLNKMKLSLGTSYVGQFEVSTIDHIFQMVLKVVAIPIANVYLAEGYPLPALGKMQFVNPQLQILKDSILLSTDVQFTG
    

Molecular Weight51381.31 Da

Isoelectric Point (pI)9.26

Net Charge (pH 7.0)10.82

Net Charge (pH 7.4) 10.24

Charge Density (pH 7.0) 0.0229

GRAVY Index0.23

Hydrophobic Moment 0.94

Boman Index0.17

Instability Index33.05

Aliphatic Index 107.16

Aromaticity 0.0847

Extinction Coeff. Reduced 38850.00

Extinction Coeff. Oxidized 39100.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0305467 VERIFIED: NO

Provenance & Taxonomy

OrganismAustrofundulus limnaeus [Bacterium]

FamilyBPI

Tax ID52670

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence