Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length414 amino acids

Chemical FormulaC2124H3301N519O600S15

DescriptionStandard

        MWLVAIVLLLGITQTNAEYPALQAALSQKGLQKVSHWVTDWLQKELTIITLPEVTGRVNVILGYVYYTLHDMTIVRCDLPEPSVSFSEGTGLSLQLHGLSIAINGLWDTNFGIIHDGGWFDMAVYTINLDTLLEFQNTEEHLSITAFMCTAKVEDVQINFHGGASFLFRRWVEKFKGHITNMVQKRVDTIKLDSYVYLNISLTDSPVVYDNGFELNVKYSARSPSEPPFSPNYFKLPWLPDYMLSVGVSEFCINSAAFAYHKSGVLSINITDGMIPKTSPVHLNTSQLGFLIPQLPKLYPDMEMEVMLYATDAPLISFNQTVINVDLSAAAKFTAIKTPTHLIPLFRLDMIAPIKTLLEKVISSVVLPKLNAQLKDGLPLPTVKGFSLNKSVMTVENGFVFLATDLNSPFQSLQ
    

Molecular Weight46188.02 Da

Isoelectric Point (pI)5.56

Net Charge (pH 7.0)-8.62

Net Charge (pH 7.4) -9.48

Charge Density (pH 7.0) -0.0208

GRAVY Index0.21

Hydrophobic Moment 0.70

Boman Index0.20

Instability Index38.87

Aliphatic Index 105.68

Aromaticity 0.1039

Extinction Coeff. Reduced 59360.00

Extinction Coeff. Oxidized 59485.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0389942 VERIFIED: NO

Provenance & Taxonomy

OrganismBagarius yarrelli [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence