Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length507 amino acids

Chemical FormulaC2564H3997N647O737S19

DescriptionStandard

        MRTKAVQVLWGCFFLWSLHISSAQTIYPGIKARVTQRALDYGVLAGMDMIEQMVKERNIPDLRGSESLEFLKVDYVNYNFSNIKINAFSFPNTSLAFVPGVGIKALTNHGTANISTDWEIRSPLFQDTGGADLFLSGVYFTGIIVLARNGFGHPILKLQDCYAQVSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIIMSEVEALNANLSMLEVLTKIDNYTLLDYSLISSPEITENYMELNLKGVFYPLDNLTDPPFSPVPFVLPERSDSMLYVGISEFFFKSASFAYFTAGAFNVTLSMKEISNHLVQNSQGLGNVLSRIAEIYILSQPFMVRVMATEPPVISLQPGNFTLDIPASIVLLAQTENSTAEAIVSMDFVASTSVGLVILGQRLVCSLSLNRFRLSLPESNRSNIEVLRFENVLSSILHFGILPLANAKLQQGIPLPNPRKISFVNSDIEVFEGFLLISTDLKYEMSLKQQPSFHGWEGLNLISGQWRGKPAA
    

Molecular Weight56287.29 Da

Isoelectric Point (pI)5.31

Net Charge (pH 7.0)-10.77

Net Charge (pH 7.4) -11.56

Charge Density (pH 7.0) -0.0213

GRAVY Index0.19

Hydrophobic Moment 0.68

Boman Index0.18

Instability Index40.08

Aliphatic Index 103.63

Aromaticity 0.1026

Extinction Coeff. Reduced 49850.00

Extinction Coeff. Oxidized 50100.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0186803 VERIFIED: NO

Provenance & Taxonomy

OrganismUrsus maritimus [Animal]

FamilyBPI

Tax ID29073

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence