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MYP_051057
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Basic Information
Anoplin[5-9]
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
not Standard
10 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GLLKXIKTXL
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0065446 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
(S)-2-(4?-pentenyl)-alanine, O5-O9: stapled at 5,9; (S)-2-(4?-pentenyl)-alanine, O5-O9: stapled; Hydrocarbon staple / ring-closing metathesis constraint
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli WR 3551/98 ESBL+
16 μM
MIC
PMID34966367 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34966367/
RECORD: Rec_0075515 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
(S)-2-(4?-pentenyl)-alanine, O5-O9: stapled at 5,9; (S)-2-(4?-pentenyl)-alanine, O5-O9: stapled; Hydrocarbon staple / ring-closing metathesis constraint
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa ATCC 27853
32 μM
MIC
PMID34966367 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34966367/
RECORD: Rec_0078041 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
(S)-2-(4?-pentenyl)-alanine, O5-O9: linear at 5,9; (S)-2-(4?-pentenyl)-alanine, O5-O9: linear
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli WR 3551/98 ESBL+
4 μM
MIC
PMID34966367 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34966367/
RECORD: Rec_0087362 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
(S)-2-(4?-pentenyl)-alanine, O5-O9: linear at 5,9; (S)-2-(4?-pentenyl)-alanine, O5-O9: linear
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa ATCC 27853
16 μM
MIC
PMID34966367 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34966367/
RECORD: Rec_0096399 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
(S)-2-(4?-pentenyl)-alanine, O5-O9: stapled at 5,9; (S)-2-(4?-pentenyl)-alanine, O5-O9: stapled; Hydrocarbon staple / ring-closing metathesis constraint
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli 1841/06 ESBL+
8 μM
MIC
PMID34966367 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34966367/
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