Peptide Database

Peptide NameSLAY-screened peptide P819

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC111H179N31O32

DescriptionStandard

        YRVQPDDNVLQVRVTVAIIFN
    

Molecular Weight2459.80 Da

Isoelectric Point (pI)5.96

Net Charge (pH 7.0)-0.24

Net Charge (pH 7.4) -0.44

Charge Density (pH 7.0) -0.0114

GRAVY Index0.23

Hydrophobic Moment 0.27

Boman Index0.06

Instability Index14.94

Aliphatic Index 129.52

Aromaticity 0.0952

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1047.75

LogP -8.63

H-bond Donors 35.0

H-bond Acceptors 32.0

Rotatable Bonds 78.0

Heavy Atoms 174.0

Ring Count 3.0

Amide Bonds 24.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0086409 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/