Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length596 amino acids

Chemical FormulaC2936H4618N806O822S26

DescriptionStandard

        MLTHLRVDCRLGFTGRSASDKDPPSLDTAIQHALAGLYPPFEATAPTILGQVFRLLDSDFQGDGLSFLLDFLIPAKRLCEQVREAACLGANHAYAFIQEEVLDKRHPCVMAPRSLSWGWHCGQHQAALAEAANRHVLSTYWMPGAILRINQETGKNLSCQQGVAVLQKELEKITIPTSSGSFKIKHLGKGHYSFHSMAIRGFQLPSSQIKLAPSEGLDLSIANANVKMSGKWKARKNFIKTSGNFDLSVEGVSISAVLKLGFDPASGHCTVSCSRCSNHINSVRVHISGSSLGWLINLFHEKMESSLRNRMTSEICKVVTSSVSSKLQRYLETLPVTTRIDHVAGINYSLVAPPTATTDSLDGQLKGEFFRWAHPSPPPFAPPPLAFPSDHDRMVYLGISNYFFNTAGFVYQQAGVLNLTVTDNVIPKESKFRLTTDVFGIFIPQVRKSLFPFGPLMRHPGATLDAQAFAVLPNSSLAPLFVLRLSMNISVTVGATPDRLVGQVSLNRSHGMLILSYTRPNLPGGILLNPWRAFSRIPEMPPKSPTKWVEVLQAVMNYVVPIAVIPKSSCPGLCPPPLLAFPAHLPQASSRLCATQ
    

Molecular Weight65192.67 Da

Isoelectric Point (pI)9.31

Net Charge (pH 7.0)17.15

Net Charge (pH 7.4) 15.64

Charge Density (pH 7.0) 0.0288

GRAVY Index0.01

Hydrophobic Moment 0.76

Boman Index0.10

Instability Index45.14

Aliphatic Index 90.99

Aromaticity 0.0822

Extinction Coeff. Reduced 60390.00

Extinction Coeff. Oxidized 61140.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0231199 VERIFIED: NO

Provenance & Taxonomy

OrganismPuma concolor (Mountain lion) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria